ZIA CP010123 02365 (ZIA) | |||
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Title | Breast cancer among a DDT exposed population in Triana, AL | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hoover, Robert | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $94,821 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
The NCI, in collaboration with the Triana Area Medical Fund and the College of Nursing at the University of AL -Huntsville, is conducitng a study to investigate the possible effects of environmental exposures, such as the pesticide DDT and other organochlorine compunds, on the risk of breast cancer. The objectives of this study is to evaluate the risk of breast cancer associated with organochlorine exposures among predominantly African-American women. This project is comprised of two major components (1) comparison of blood serum levels of DDT, DDE and other organochlorine compounds (PCBs, hexachorobenzene, <font face=""Symbol"">b</font>-benzene hexachloride, oxychlordane, trans-nonachlor, and heptachlor epoxide) among members of the Trianan Area Medical Fund population with a high percentage of mammographic densities to women without this condition and (2) methodologic investigations on organochlorine retention/decay patterns within the well-characterized Triana Area Medical Fund. A poster on changes in DDT/DDE levels between 1976 and 1998 was developed in 2005. Other analyses are underway. |